| 书名： | 生物化学(留学生与双语教学用)(英文原版改编版） |
| 出版社： | 清华大学出版社 |
| 出版日期 | 2021 |
| ISBN号： | 9787302577010 |
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| The fourth edition of Biochemistry preserves the clear writing, strong physical chemistry background, and the use of the "Tools of Biochemistry" feature to underscore the experimental nature of biochemistry. This edition has been comprehensively and consistently updated to present the current developments in a rapidly evolving field. |
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| 杨洁，教授，博导。1997年7月中山医科大学生化博士毕业后执教医学基础课程-生化与分子生物学多年，承担了五年制、七年制、留学生和研究生的《生物化学》课程以及研究生的《分子生物学进展》等课程，积累了大量教育教学经验。2007年被评为天津市优秀教师，国家教育部新世纪人才支持计划、天津市特聘教授。参编专著《分子遗传学与基因工程》，人卫教材《医学细胞生物学》、《医学免疫学》。现今为中华医学会医学细胞生物学常务委员、中华微生物与免疫学会青年委员会副主委、临床生物化学与分子生物学会理事、中国细胞生物学会医学细胞生物学分会理事、天津市生化与分子生物学常务理事。作为基础医学院的院长，对基础医学课程体系及规范课程的改革和优化做出了积极的推动作用。作为211重点学科带头人，2006年以来获得863、国家基金面上、重大研究计划培育等科研项目，在Nat Struct Mol Biol.，JBC.，NAR等国际杂志发表SCI收录论文10余篇，培养研究生18名。 |
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| 《生物化学》第四版保留了清晰的文字、强有力的物理化学背景，并使用“生物化学工具”的特点来强调生物化学的实验性质。这一版已经全面和一致地更新，以目前在一个快速发展的领域的发展。 |
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| Contents 目录 PART 1 The Realm of Biochemistry CHAPTER 1 The Scope of Biochemistry 3 Biochemistry and the Biological Revolution3 The Roots of Biochemistry 4 Biochemistry as a Chemical Science7 Biochemistry as a Biological Science 10 Biochemistry and the Information Explosion 13 PART 2 Molecular Architecture of Living Matter CHAPTER 2 Nucleic Acids17 The Nature of Nucleic Acids 17 Primary Structure of Nucleic Acids22 Secondary and Tertiary Structure of Nucleic Acids 24 The Biological Functions of Nucleic Acids: A Preview of Molecular Biology35 Plasticity of Secondary and Tertiary DNA Structure 40 Stability of Secondary and Tertiary Structure43 CHAPTER 3 Introduction to Proteins: The Primary Level of Protein Structure 46 Amino Acids 46 Peptides and the Peptide Bond 55 Proteins: Polypeptides of Defined Sequence58 From Gene to Protein60 Protein Sequence Homology 61 CHAPTER 4 The Three-Dimensional Structure of Proteins64 Secondary Structure: Regular Ways to Fold the Polypeptide Chain64 Fibrous Proteins: Structural Materials of Cells and Tissues 71 Globular Proteins: Tertiary Structure and Functional Diversity76 Factors Determining Secondary and Tertiary Structure 79 Prediction of Secondary and Tertiary Protein Structure88 Quaternary Structure of Proteins88 CHAPTER 5 Protein Function and Evolution93 Oxygen Transport: The Roles of Hemoglobin and Myoglobin94 The Mechanism of Oxygen Binding by Heme Proteins 95 Oxygen Transport: Hemoglobin100 Allosteric Effectors of Hemoglobin 110 Protein Evolution: Myoglobin and Hemoglobin as Examples114 Hemoglobin Variants: Evolution in Progress 118 PART 3 Dynamics of Life: Catalysis and Metabolism CHAPTER 6 Enzymes: Biological Catalysts 127 The Role of Enzymes 127 Chemical Reaction Rates and the Effects of Catalysts: A Review 127 How Enzymes Act as Catalysts: Principles and Examples131 Enzyme Inhibition142 Cofactors, Vitamins, and Essential Metals 146 The Diversity of Enzymatic Function148 Nonprotein Biocatalysts: Catalytic Nucleic Acids 148 The Regulation of Enzyme Activity: Allosteric Enzymes 151 Covalent Modifications Used to Regulate Enzyme Activity 154 CHAPTER 7 Chemical Logic of Metabolism159 A First Look at Metabolism 159 Freeways on the Metabolic Road Map161 Biochemical Reaction Types 165 Some Bioenergetic Considerations 165 Major Metabolic Control Mechanisms171 CHAPTER 8 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway 176 Glycolysis: An Overview 176 Reactions of Glycolysis178 Metabolic Fates of Pyruvate 185 Energy and Electron Balance Sheets186 Gluconeogenesis188 Coordinated Regulation of Glycolysis and Gluconeogenesis 192 Entry of Other Sugars into the Glycolytic Pathway197 Polysaccharide Metabolism200 Glycogen Metabolism in Muscle and Liver 200 Coordinated Regulation of Glycogen Metabolism203 Biosynthesis of Other Polysaccharides 208 A Biosynthetic Pathway That Oxidizes Glucose: The Pentose Phosphate Pathway208 CHAPTER 9 Citric Acid Cycle216 Overview of Pyruvate Oxidation and the Citric Acid Cycle216 Pyruvate Oxidation: A Major Entry Route for Carbon into the Citric Acid Cycle219 Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle 221 Action of the Pyruvate Dehydrogenase Complex223 The Citric Acid Cycle225 Stoichiometry and Energetics of the Citric Acid Cycle 229 Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle 230 CHAPTER 10 Electron Transport and Oxidative Phosphorylation234 Electron Transport 236 Oxidative Phosphorylation247 CHAPTER 11 Lipid MetabolismⅠ: Fatty Acids, Triacylglycerols, and Lipoproteins263 Utilization and Transport of Fat and Cholesterol 263 Fatty Acid Oxidation 277 Fatty Acid Biosynthesis287 CHAPTER 12 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates 301 Interdependence of the Major Organs in Vertebrate Fuel Metabolism 301 Hormonal Regulation of Fuel Metabolism305 Responses to Metabolic Stress: Starvation, Diabetes 310 CHAPTER 13 Lipid Metabolism Ⅱ: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids315 Metabolism of Glycerophospholipids315 Metabolism of Sphingolipids 322 Steroid Metabolism323 Other Isoprenoid Compounds 328 Eicosanoids: Prostaglandins, Thromboxanes, and Leukotrienes330 CHAPTER 14 Metabolism of Nitrogenous CompoundsⅠ: Principles of Biosynthesis, Utilization, and Turnover336 Utilization of Ammonia: Biogenesis of Organic Nitrogen336 The Nitrogen Economy: Aspects of Amino Acid Synthesis and Degradation 338 Protein Turnover340 Amino Acid Degradation and Metabolism of Nitrogenous End Products342 Coenzymes Involved in Nitrogen Metabolism347 CHAPTER 15 Metabolism of Nitrogenous Compounds Ⅱ: Amino Acids, Porphyrins, and Neurotransmitters 355 Pathways of Amino Acid Degradation355 Amino Acids as Biosynthetic Precursors359 Porphyrin and Heme Metabolism 364 Amino Acids and Their Metabolites as Neurotransmitters and Biological Regulators 367 Amino Acid Biosynthesis369 Methionine as the Source of Cysteine Sulfur in Animals370 CHAPTER 16 Nucleotide Metabolism372 Outlines of Pathways in Nucleotide Metabolism372 De Novo Biosynthesis of Purine Nucleotides375 Purine Degradation and Clinical Disorders of Purine Metabolism379 Pyrimidine Nucleotide Metabolism 383 Deoxyribonucleotide Biosynthesis and Metabolism386 Thymidylate Synthase: A Target Enzyme for Chemotherapy 391 Biological and Medical Importance of Other Nucleotide Analogs394 CHAPTER 17 Mechanisms of Signal Transduction 398 An Overview of Hormone Action 398 Hierarchical Nature of Hormonal Control400 Synthesis of Peptide Hormone Precursors401 Signal Transduction: Receptors402 Transducers: G Proteins 404 Effectors: Adenylate Cyclase407 Second-Messenger Systems408 Receptor Tyrosine Kinases412 Steroid and Thyroid Hormones: Intracellular Receptors415 Signal Transduction, Oncogenes, and Cancer 418 PART 4 Information CHAPTER 18 Genes, Genomes, and Chromosomes 427 Prokaryotic and Eukaryotic Genomes 427 Restriction and Modification 430 Determining Genome Nucleotide Sequences 433 Physical Organization of Genes: The Nucleus, Chromosomes, and Chromatin435 CHAPTER 19 DNA Replication442 Early Insights into DNA Replication442 DNA Polymerases: Enzymes Catalyzing Polynucleotide Chain Elongation443 Multiple DNA Polymerases 445 Other Proteins at the Replication Fork445 Proteins in Eukaryotic DNA Replication449 Replication of Chromatin449 Initiation of DNA Replication 450 Replication of Linear Genomes452 Fidelity of DNA Replication453 RNA Viruses: The Replication of RNA Genomes 454 CHAPTER 20 DNA Restructuring: Repair, Recombination, Rearrangement, Amplification 457 DNA Repair 457 Mismatch Repair 464 Recombination470 Gene Rearrangements 475 Gene Amplification477 CHAPTER 21 Information Readout: Transcription and Post-transcriptional Processing479 DNA as the Template for RNA Synthesis 480 Enzymology of RNA Synthesis: RNA Polymerase480 Mechanism of Transcription483 Transcription and Its Control in Eukaryotic Cells 489 Post-transcriptional Processing498 CHAPTER 22 Information Decoding: Translation and Post-translational Protein Processing 506 An Overview of Translation506 The Genetic Code 506 The Major Participants in Translation: mRNA, tRNA, and Ribosomes509 Mechanism of Translation 515 Inhibition of Translation by Antibiotics520 Translation in Eukaryotes522 Rates and Energetics of Translation 524 The Final Stages in Protein Synthesis: Folding and Covalent Modification 525 Protein Targeting in Eukaryotes 527 CHAPTER 23 Regulation of Gene Expression533 Regulation of Transcription in Bacteria 533 Transcriptional Regulation in Eukaryotes540 DNA Methylation, Gene Silencing, and Epigenetics543 Regulation of Translation546 RNA Interference 550 RNA Editing 552 |
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| 新时代的中国软实力与日俱增，来华学医成为众多留学生的首选。高质量的临床医学专业的全英文教材对于提升留学生的培养质量至关重要。在临床医学专业留学生教材建设专家指导委员会和清华大学出版社的支持下，我们完成了这本《生物化学》教材的改编工作。本教材在充分尊重原著的基础上，保留其基本框架，参考清华大学出版社出版的《来华留学生临床医学专业本科（英语授课）教学大纲》和国家执业医师资格考试大纲进行改编，内容涵盖大分子结构与功能、物质代谢与调节，以及遗传信息传递等。本书编排上力求简明扼要，重点突出，可作为来华留学临床医学学士（MBBS）和我国长学制临床医学专业学生使用的教材，也可作为相关学科的硕士研究生、进修生和教师的参考书。 在各医学院校推荐的基础上，本教材改编委员会遴选出天津医科大学杨洁教授担任主审，25所医学院校的编委共同完成了本教材的改编工作。由于改编者的知识局限，本教材难免存在缺点和错误，敬请同行专家、使用本教材的师生和其他读者批评指正。
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