Contributors vii
Preface ix
SECTION I
INTRODUCTION TO THE RENAL SYSTEM
1 Cellular and Molecular Biology of the Kidney 2
Alfred L George, Jr, Eric G Neilson
2 Adaptation of the Kidney to Injury 16
Joseph V Bonventre
SECTION II
ALTERATIONS OF RENAL FUNCTION AND ELECTROLYTES
3 Azotemia and Urinary Abnormalities 24
Julie Lin, Bradley M Denker
4 Atlas of Urinary Sediments and Renal Biopsies 33
Agnes B Fogo, Eric G Neilson
5 Acidosis and Alkalosis 45
Thomas D DuBose, Jr
6 Fluid and Electrolyte Disturbances 58
David B Mount
7 Hypercalcemia and Hypocalcemia 84
Sundeep Khosla
8 Gout and Other Crystal-Associated
Arthropathies 88
H Ralph Schumacher, Lan X Chen
9 Nephrolithiasis 95
Gary C Curhan
SECTION III
ACUTE KNEY INJURY AND CHRONIC RENAL FAILURE
10 Acute Kidney Injury 104
Sushrut S Waikar, Joseph V Bonventre
11 Chronic Kidney Disease 122
Joanne M Bargman, Karl Skorecki
12 Dialysis in the Treatment of Renal Failure 138
Kathleen D Liu, Glenn M Chertow
13 Transplantation in the Treatment of
Renal Failure 145
Jamil Azzi, Edgar L Milford,
Mohamed H Sayegh, Anil Chandraker
14 Infections in Transplant Recipients 155
W Finberg Robert, Joyce Fingeroth
SECTION IV
GLOMERULAR AND TUBULAR DISORDERS
15 Glomerular Diseases 174
Julia B Lewis, Eric G Neilson
16 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and
Development 202
Jing Zhou, Martin R Pollak
17 Tubulointerstitial Diseases of the Kidney 212
Laurence H Beck, David J Salant
SECTION V
RENL ACUAR DISEASE
18 Vascular Injury to the Kidney 224
Nelson Leung, Stephen C Textor
19 Hyresive Vascular Disease 0
Theodore A Kotchen
20 Renovascular Disease 254
Stephen C Textor
SECTION VI
URINARY TRACT INFECTIONS AND OBSTRUCTION
21 Urinary Tract Infections, Pyelonephritis, and
Prostatitis 262
Kalpana Gupta, Barbara W Trautner
22 Urinary Tract Obstruction 273
Julian L Seifter
Bladder and Renal Cell Carioas 278
Howard I Scher, Jonathan E Rosenberg,
Robert J Motzer
CONTENTS
Harrison_
Appendix
Laboratory Values of Clinical Importance 285
Alexander Kratz, Michael A Pesce,
Robert C Basner, Andrew J Einstein
Review and Self-Assessment 303
Charles M Wiener, Cynthia D Brown,
Brian Houston
Index 3