Preface Acknowledgements Notes on using The Maudsley Prescribing Guidelines List of abbreviations Chapter 1 Plasma level monitoring of psychotropic drugs Interpreting sample results Acting on clozapine plasma concentration results Interpreting post-mortem blood concentrations Chapter 2 Schizophrenia ANTIPSYCHOTC RUGS General introduction General principles of prescribing Minimum effective doses ick reference for licensed maximum doses Equivalent doses High?dose antipsychotics: prescribing and monitoring Antipsychotic prophylaxis Combined antipsychotics Negative sytm Monitoring Relative adverse effecs? rugh guide Treatment algorithms for schizophrenia First?generation antipsychotics?place in therapy Omega?3 fatty acid (fish oils) in schizophrenia New and developing drugs to treat schizophrenia NICE guidelines for the treatment of schizophrenia Antipsychotic response ? to increase the dose, to switch,to add or just wait ? what is the right move? Antipsychotic long?acting injections Depot antipsychotics ? pharmacokinetics Management of patients on long?term depots Aripiprazole LAI Olanzapine LAI Paliperidone palmitate LAI Risperidone LAI ANTIPSYCHOT ICS ? DER E EFFECTS Extrapyramidal side?effects Akathisia Weight gain Treatment of drug?induced weight gain Tardive dyskinesia Neuroleptic malignant synoe Catatonia T prolongation Dyslipidaemia Diabetes and impaired glucose tolerance Hyresion Hyponatraemia Hyperprolatiaeia Sexual dysfunction Pneumonia Switching antipsychotics REFRACTORY SCHIZOPHRENIA AND CLOZAPINE Clozapine ? dosing regimen Optimising clozapine treatment Alternatives to clozapine Re?starting clozapine after a break in treatment Initiation of clozapine for community?based patients CLOZAPINE ? DER E EFFECTS Common adverse effects Clozapine: uncommon or unusual adverse effects Clozapine: serious haematological and cardiovascular adverse effects Clozapine?indu