Chapter 1 Introduction 1
1 Bacteria 1
2 Viruses 1
3 Fungi 1
4 Chapter Summary 2
Review estions 2
Chapter 2 Cell Structure 3
1 Prokaryotic Cell Structure 3
2 Staining 22
3 Morphologic Changes During Growth
4 Chapter Summary
Review estions 24
Chapter 3 Bacterial Physiology 25
1 Classification of Bacteria 25
2 The Growth, Survival, and Death of Microorganisms 35
3 Cultivation of Microorganisms 41
4 Microbial Metabolism 50
5 Chapter Summary 61
Review estions 62
Chapter 4 Bacterial Genetics 65
1 The Prokaryotic Genome 65
2 Bacteriophage 67
3 Transfer of DNA 68
4 Mutations and Selection 74
5 Applications of Bacterial Genetics 76
6 Chapter Summary 77
Review estions 77
Chapter 5 Normal Human Microbiota 78
1 Role of the Resident Microbiota 78
2 Normal Microbiota of the Skin 79
3 Normal Microbiota of the Mouth and Upper Respiratory Tract 79
4 Normal Microbiota of the Urethra 83
5 Normal Microbiota of the Vagina 83
6 Normal Microbiota of the Conjunctiva 83
7 Chapter Summary 83
Review estions 84
Chapter 6 Bacterial Infection and Immunity 86
1 Overview 86
2 Pathogenesis of Bacterial Infections 86
3 Immunity of Bacterial Infections 96
4 Chapter Summary 112
Review estions 113
Chapter 7 Laboratory Diagnosis, TreatmenndPrphylaxis of Bacterial Infection 116
1 Laboratory Diagnosis of Bacterial Infection 116
2 TreatmenndPrphylaxis of Bac terial Infection 122
Review estions 130
Chapter 8 Pathogenic Coccus 132
1 The Staphylococci 132
2 The Streptococci 138
3 The Entercocci 146
4 The Neisseria 147
5 Chapter Summary 152
Review estions 153
Chapter 9 Enteric Gram-negative Rods (Enterobacteriaceae) 155
1 Classification 155
2 Diseases Caused by Enterobac teriaceae Other Than Salmonella and Shigella 159
3 The Shigellae 162
4 The Salmonella-Arizona Group 163
5 Chapter Summary 166
Review estions 167
Chapter 10 Vibrios, Campylobacters,Helicobacter, and Associated Bacteria 169
1 The Vibris 69
2 Campylobacter 171
Review estions 174
Chapter 11 Spore-forming Gra-itive Bacilli: Bacillus and Clostridium Species 176
1 Bacillus Species 176
2 Bacillus Anthracis 176
3 Bacillus Cereus 178
4 Clostridium Species 179
5 Clostridium Botulinum 179
6 Clostridium Tetani 180
7 Clostridia That Produce Invasive Infections 181
8 Clostridium Difficile and Diarrheal Disease 183
Review estions 183
Chapter 12 Infections Caused by Anaerobic Bacteria 185
1 Anaerobic Bacteria Found in Hu man Infections 185
2 Pathogenesis of Anaerobic Infec tions 187
3 The Polymicrobial Nature of Anae robic Infections 187
4 Diagnosis of Anaerobic Infections 188
5 Treatment of Anaerobic Infections 188
6 Chapter Summary 188
Review estions 188
Chapter 13 Mycobacteria 190
1 Mycobacterium Tuberculosis 190
2 Mycobacterium Leprae 192
3 Chapter Summary 192
Review estions 192
Chapter 14 Aerobic Non-Spore-Forming Gra-itive Bacilli 193
1 Corynebacterium Diphtheriae 194
2 Other Coryneform Bacteria 197
3 Listeria Monocytogenes 197
4 Atioycetes 198
5 Nocardiosis 199
6 Atioycetoma 199
7 Chapter Summary 200
Review estions 200
Chapter 15 Pseudomonads and Acinetobacters 202
1 Pseudomonads 202
2 Acinetobacter 206
3 Chapter Summary 207
Review estions 207
Chapter 16 Haemophilus, Bordetella,Brucella, Francisella 209
1 Haemophilus 209
2 Bordetella 210
3 Brucella 212
4 Francisella 214
5 Chapter Summary 215
Review estions 216
Chapter 17 Yersinia and Pasteurlla 217
1 Yersinia 217
2 Pasteurella 219
Review estions 220
Chapter 18 Legionellae, Bartonella, and Unusual Bacterial Pathogens 222
1 Legionella Pneumophila and Other Legionellae 222
2 Bartonella 2
3 Streptobacillus Moniliformis 224
4 Chapter Summary 225
Review estions 225
Chapter 19 Spirochetes and Other Spiral Microorganisms 227
1 Treponema Pallidum and Syphilis 227
2 Borrelia Burgdorferi and Lyme Disease 229
3 Leptospira and Leptospirosis 1
Review estions
Chapter 20 Mycoplasma and Cell
Wall-Defective Bacteria 4
1 General Introduction 4
2 Mycoplasma Pneumoniae
3 Other Pathogenic Mycoplasma
4 Cell Wall-Defective Bacteria
5 Chapter Summary
Review estions
Chapter 21 Rickettsia and Related Genera 240
1 General 240
2 Rickettsia and Orientia 240
3 Coxiella Burnetii 243
4 Ehrlichia and Anaplasma 244
5 Chapter Summary 245
Review estions 245
Chapter 22 Chlamydiae 247
1 General Properties of Chlamydia 247
2 Diseases 249
3 Chapter Summary 254
Review estions 255
Chapter General Properties of Viruses 257
1 Classification of Viruses 257
2 Virus Structure 258
3 Chemical Coition of Viruses 261
4 Replication of Viruses 262
5 Genetics of Animal Viruses 266
6 Natural History (Ecology) and Modes of Transmission of Viruses 268
7 Reaction to Physical and Chemical Agents 270
8 Laboratory Techniques of Virology 271
9 Chapter Summary 273
Review estions 273
Chapter 24 Viral Infection and Immune Response to Viruses 276
1 The Modes and Types of Viral Infec tion and Pathogenicity of Viruses 276
2 Anti-Virus immunity 285
3 Chapter Summary 290
Review estions 290
Chapter 25 Diagnosis, Treatment and Prevention of Viral Infection 292
1 Diagnosis of Viral Infection 292
2 Treatment of Viral Infection 298
3 Prevention of Viral Infection 299
4 Chapter Summary 301
Review estions 302
Chapter 26 Orthomyxoviruses (Influenza Viruses), Paramyxoviruses and Rubella Virus 304
1 Orthomyxoviruses (Influenza Vir us) 304
2 Paramyxoviruses and Rubella Virus 314
3 Chapter Summary 331
Review estions 332
Chapter 27 Coronaviruses and Adenoviruses 335
1 Coronaviruses 335
2 Adenoviruses 338
3 Chapter Summary 343
Review estions 343
Chapter 28 Picornaviruses (Enterovirus and Rhinovirus Groups) 345
1 Properties of Picornaviruses 345
2 Enterovirus Group 346
3 Rhinoviruses 351
4 Other Picornaviruses 352
5 Chapter Summary 352
Review estions 352
Chapter 29 Reoviruses, Rotaviruses and
Caliciviruses 354
1 General Properties of Reoviridae 354
2 Rotaviruses 355
3 Reoviruses and Caliciviridae 358
4 Chapter Summary 359
Review estions 359
Chapter 30 Hepatitis Viruses 361
1 Properties of Hepatitis Viruses 361
2 Hepatitis Virus Infections in Humans 367
3 Chapter Summary 376
Review estions 377
Chapter 31 AS and Lentiviruses 380
1 Properties of Lentiviruses 380
2 HIV Infections in Humans 384
3 Chapter Summary 392
Review estions 392
Chapter 32 Herpesviruses 394
1 General Properties of Herpesvi ru ses 394
2 Herpesvirus Infections in Humans 396
3 Chapter Summary 408
Review estions 408
Chapter 33 Arthropod-Borne and Rodent-Borne Viral Diseases 410
1 Arbovirus Infections 410
2 Hemorrhagic Fever Virus Infections 414
3 Chapter Summary 417
Review estions 418
Chapter 34 Poxviruses and Parvoviruses 420
1 Poxviruses 420
2 Parvoviruses 426
3 Chapter Summary 430
Review estions 430
Chapter 35 Rabies, Slow Virus Infections,and Prion Diseases 432
1 Rabies 432
2 Slow Virus Infections and Prion Dis eases 437
3 Chapter Summary 439
Review estions 440
Chapter 36 Medical Mycology 442
1 General Property of Fungi 442
2 Pathogenic Fungi 444
3 Chapter Summary 448
Review estions 449
Chapter 37 Cases and Clinical Correlations 452
1 Central Nervous System 452
2 Respiratory 456
3 Heart 460
4 Abdomen 461
5 Urinary Tract 463
6 Bone and Soft Tissue 468
7 Sexually Transmitted Diseases 470
8 Mycobacterium Tuberculosis In fections 472
9 HIV-1 and AS 475
10 Infections in Transplant Patients 479
11 Biologic Warfare and Bioterrorism 483
Chinese-English Vocabulary 488
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