正版新书]生物化学 留学生与双语教学用(原著第4版) 英文原版改

PART 1 The Realm of Biochemistry

CHAPTER 1 The Scope of Biochemistry

Biochemistry and the Biological Revolution

The Roots of Biochemistry

Biochemistry as a Chemical Science

Biochemistry as a Biological Science

Biochemistry and the Information Explosion

PART 2 Molecular Architecture of Living Matter

CHAPTER 2 Nucleic Acids

The Nature of Nucleic Acids

Primary Structure of Nucleic Acids

Secondary and Tertiary Structure of Nucleic Acids

The Biological Functions of Nucleic Acids:A Preview of Molecular Biology

Plasticity of Secondary and Tertiary DNA Structure

Stability of Secondary and Tertiary Structure

CHAPTER 3 Introduction to Proteins:The Primary Level of Protein Structure

Amino Acids

Peptides and the Peptide Bond

Proteins:Polypeptides of Defined Sequence

From Gene to Protein

Protein Sequence Homology

CHAPTER 4 The Three-Dimensional Structure of Proteins

Secondary Structure:Regular Ways to Fold the Polypeptide Chain

Fibrous Proteins:Structural Materials of Cells and Tissues

Globular Proteins:Tertiary Structure and Functional Diversity

Factors Determining Secondary and Tertiary Structure

Prediction of Secondary and Tertiary Protein Structure

Quaternary Structure of Proteins

CHAPTER 5 Protein Function and Evolution

Oxygen Transport:The Roles of Hemoglobin and Myoglobin

The Mechanism of Oxygen Binding by Heme Proteins

Oxygen Transport:Hemoglobin

Allosteric Effectors of Hemoglobin

Protein Evolution:Myoglobin and Hemoglobin as Examples

Hemoglobin Variants:Evolution in Progress

PART 3 Dynamics of Life:Catalysis and Metabolism

CHAPTER 6 Enzymes:Biological Catalysts

The Role of Enzymes

Chemical Reaction Rates and the Effects of Catalysts:A Review

How Enzymes Act as Catalysts:Principles and Examples

Enzyme Inhibition

Cofactors,Vitamins,and Essential Metals

The Diversity of Enzymatic Function

Nonprotein Biocatalysts:Catalytic Nucleic Acids

The Regulation of Enzyme Activity:Allosteric Enzymes

Covalent Modifications Used to Regulate Enzyme Activity

CHAPTER 7 Chemical Logic of Metabolism

A First Look at Metabolism

Freeways on the Metabolic Road Map

Biochemical Reaction Types

Some Bioenergetic Considerations

Major Metabolic Control Mechanisms

CHAPTER 8 Carbohydrate Metabolism:Glycolysis,Gluconeogenesis,Glycogen Metabolism,and the Pentose Phosphate Pathway

Glycolysis:An Overview

Reactions of Glycolysis

Metabolic Fates of Pyruvate

Energy and Electron Balance Sheets

Gluconeogenesis

Coordinated Regulation of Glycolysis and Gluconeogenesis

Entry of Other Sugars into the Glycolytic Pathway

Polysaccharide Metabolism

Glycogen Metabolism in Muscle and Liver

Coordinated Regulation of Glycogen Metabolism

Biosynthesis of Other Polysaccharides

A Biosynthetic Pathway That Oxidizes Glucose:The Pentose Phosphate Pathway

CHAPTER 9 Citric Acid Cycle

Overview of Pyruvate Oxidation and the Citric Acid Cycle

Pyruvate Oxidation:A Major Entry Route for Carbon into the Citric Acid Cycle

Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle

Action of the Pyruvate Dehydrogenase Complex

The Citric Acid Cycle

Stoichiometry and Energetics of the Citric Acid Cycle

Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle

CHAPTER 10 Electron Transport and Oxidative Phosphorylation

Electron Transport

Oxidative Phosphorylation

CHAPTER 11 Lipid MetabolismⅠ:Fatty Acids,Triacylglycerols,and Lipoproteins

Utilization and Transport of Fat and Cholesterol

Fatty Acid Oxidation

Fatty Acid Biosynthesis

CHAPTER 12 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates

Interdependence of the Major Organs in Vertebrate Fuel Metabolism

……

杨洁，教授，博导。1997年7月中山医科大学生化博士毕业后执教医学基础课程-生化与分子生物学多年，承担了五年制、七年制、留学生和研究生的《生物化学》课程以及研究生的《分子生物学进展》等课程，积累了大量教育教学经验。2007年被评为天津市很好教师，国家教育部新世纪人才支持计划、天津市特聘教授。参编专著《分子遗传学与基因工程》，人卫教材《医学细胞生物学》、《医学免疫学》。现今为中华医学会医学细胞生物学常务委员、中华微生物与免疫学会青年委员会副主委、临床生物化学与分子生物学会理事、中国细胞生物学会医学细胞生物学分会理事、天津市生化与分子生物学常务理事。作为基础医学院的院长，对基础医学课程体系及规范课程的改革和优化做出了积极的推动作用。作为211重点学科带头人，2006年以来获得863、国家基金面上、重大研究计划培育等科研项目，在Nat Struct Mol Biol.，C.，NAR等靠前杂志发表SCI收录论文10余篇，培养研究生18名。

《生物化学》第四版保留了清晰的文字、强有力的物理化学背景，并使用“生物化学工具”的特点来强调生物化学的实验性质。这一版已经全面和一致地更新，以目前在一个快速发展的领域的发展。