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正版 药物剂型与工艺 张奇 化学工业出版社 9787122380906 书籍
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Chapter 1 Introduction1
1.1 Drugs and diseases1
1.1.1 Treatment of diseases1
1.1.2 Drug substances and medicines1
1.1.3 The history of drugs2
1.1.4 The drug-target interaction3
1.2 About pharmacy5
1.2.1 Pharmaceutical sciences5
1.2.2 Pharmaceutics5
1.2.3 Dosage forms and drug delivery systems6
1.2.4 Categories of DDS9
1.3 The standardization of medicine11
1.3.1 Why medicine needs standard11
1.3.2 Pharmacopeia12
1.4 Clinical using medicine12
1.4.1 Brand medicine and generic medicine12
1.4.2 Prescription medicine and over-the-counter medicine13
1.4.3 Prescription13
1.4.4 Drug-drug interaction14
1.4.5 Drug-food interaction14
References16
Chapter 2 Solid dosage forms I17
2.1 Introduction17
2.2 Powder18
2.3 Granules20
2.3.1 Preparation of granules22
2.3.2 Granulation methods and equipments22
2.3.3 Quality control of granules31
References33
Chapter 3 Solid dosage forms II34
3.1 Capsules34
3.1.1 Hard gelatin capsules34
3.1.2 Soft capsules36
3.2 Tablets37
3.2.1 Excipients of tablets39
3.2.2 Manufacture of tablets40
3.2.3 Film coating42
3.2.4 Quality control of tablets53
3.2.5 Packaging and storing of tablets58
References59
Chapter 4 Pulmonary drug delivery system60
4.1 Introduction60
4.1.1 Anatomy of lungs60
4.1.2 Advantages of pulmonary drug delivery61
4.1.3 Mechanisms of particle deposition in the lung62
4.2 Pulmonary drug delivery devices62
4.2.1 Nebulizers63
4.2.2 pMDIs64
4.2.3 DPIs64
4.2.4 Soft mist inhaler65
4.3 Factors governing aerosol deposition and targeting in the lung66
4.3.1 Aerodynamic diameter and size distribution66
4.3.2 Airflow rate66
4.3.3 Particle shape67
4.3.4 Particle density67
4.3.5 Surface roughness67
4.4 Clinical application of pulmonary drug delivery systems68
4.5 Perspectives of pulmonary drug delivery69
References70
Chapter 5 Transdermal drug delivery system73
5.1 Introduction73
5.2 Skin structure and the major obstacles of transdermal permeation74
5.3 Major transdermal routes75
5.3.1 Appendageal routes75
5.3.2 Transcellular routes75
5.3.3 Intercellular routes75
5.4 Chemical penetration enhancers76
5.4.1 Natural chemical penetration enhancers76
5.4.2 Synthetic chemical penetration enhancers77
5.4.3 Combination of penetration enhancers82
5.5 Physical techniques to improve transdermal delivery83
5.5.1 Microneedle83
5.5.2 Laser84
5.5.3 Iontophoresis86
5.5.4 Sonophoresis87
5.5.5 Electroporation89
5.5.6 Magnetophoresis90
5.5.7 Microwave90
5.6 Transdermal formulations91
5.6.1 Liposome91
5.6.2 Cubic phase91
5.6.3 Microemulsion91
5.6.4 Hydrogel91
5.6.5 Transfersome92
5.7 Device-assisted or wearable transdermal delivery systems92
5.7.1 Development stages92
5.7.2 Device93
5.7.3 Application94
5.7.4 Prospect94
References94
Chapter 6 Liquid dosage forms101
6.1 Introductions101
6.1.1 Solubilities101
6.1.2 Solvents102
6.1.3 Enhancements103
6.2 Syrups103
6.3 Elixirs104
6.4 Suspensions105
6.4.1 Sedimentation of particles in suspension105
6.4.2 Preparation of suspensions107
6.4.3 Colloidal dispersions108
6.5 Emulsions109
6.5.1 Pharmaceutical emulsions110
6.5.2 Emulsion formation theory111
6.5.3 Emulsion identification112
6.5.4 Emulsion preparation112
6.5.5 The HLB system116
6.5.6 Emulsion stability117
6.5.7 Nanoemulsions120
6.6 Creams121
6.7 Gels and magmas122
References123
Chapter 7 Sterilized preparations124
7.1 Principles of sterilization124
7.1.1 Introduction124
7.1.2 Sterilization parameters124
7.1.3 Principles of sterilization processes125
7.1.4 Gaseous sterilization127
7.1.5 Radiation sterilization128
7.1.6 Filtration sterilization129
7.1.7 High-level disinfection129
7.2 Parenteral130
7.2.1 Introduction130
7.2.2 Injections130
7.2.3 Large-volume parenterals131
7.3 Biologics131
7.3.1 Introduction131
7.3.2 Types of immunity132
7.3.3 Production of biologics132
7.4 Ophthalmic solution and suspensions133
7.4.1 Introduction133
7.4.2 Pharmaceutical requirements134
References136
Chapter 8 Modified-release oral drug delivery138
8.1 Introduction of modified-release oral drug delivery138
8.1.1 Sustained-release preparation138
8.1.2 Controlled-release preparation138
8.1.3 Delayed-release preparation138
8.2 Theories of extended-release oral drug delivery139
8.2.1 Theory of dissolution-controlled139
8.2.2 Theory of diffusion-controlled140
8.2.3 Combination of erosion and diffusion theory141
8.2.4 Osmotic pressure theory142
8.2.5 Ion exchange theory143
8.3 Design of extended-release oral drug delivery systems144
8.3.1 Properties of drugs144
8.3.2 Design requirements147
8.4 Quality assessment149
8.4.1 In vitro assessment149
8.4.2 In vivo assessment150
8.4.3 In vitro correlation150
8.5 Application of extended-release oral drug delivery systems154
8.6 Oral chronopharmacologic and oral site-specific drug delivery system160
8.6.1 Overview160
8.6.2 Theories161
8.6.3 Brief introductions163
8.6.4 Applications166
References171
Chapter 9 Suppositories173
9.1 Introduction173
9.2 Suppository bases174
9.2.1 Fatty or oleaginous bases174
9.2.2 Water-soluble or water-miscible bases174
9.3 Preparation of suppositories175
9.3.1 Manufacturing procedure175
9.3.2 Displacement value176
9.3.3 Quality control177
9.3.4 Examples177
9.4 Packing and storage178
9.5 Special types of suppositories178
References179
Chapter 10 Paediatric and geriatric drug developent180
10.1 Introduction180
10.2 Physiological changes180
10.3 Excipient safety181
10.4 Taste183
10.5 Formulation choices184
10.5.1 Tablets184
10.5.2 Liquids185
10.5.3 Multiparticulates186
10.5.4 Dispersible and orally dispersible formulations186
10.5.5 Chewable tablets187
References188
Indexes190
《Pharmaceutical Dosage Form and Technology(药物剂型与工艺)》通过介绍药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等,使读者初步了解药物制剂与工艺的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识,还可以对一些制剂的*、*前沿研究成果有所了解。本书共10章:第1章是基础知识介绍;第2章和第3章是固体药物制剂;第4章和第5章分别是肺部用药系统和透皮药物运载系统;第6章和第7章分别是液体制剂和无菌制剂;第8章是口服载药系统和该领域的*研究成果;第9章是栓剂;第10章是有关儿童患者和老年患者临床用药注意事项。本书内容精炼、通俗易懂、英语语法准确,贴合实际教学需求,有助于提高学生专业英语水平。
本书可以作为药学类专业本科生或研究生药物制剂与工艺学及相关课程的教材,也可以作为药学相关领域科研人员的参考书。
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