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本书以作者多年相关研究工作的成果积累为基础，系统阐述骨生物材料与宿主之间的相互作用。全书包括三部分。第一部分介绍生物活性材料的成骨特性、表面/界面及生物活性特征；第二部分介绍骨再生过程中生物材料诱导的微环境及其宿主反应；第三部分介绍骨再生过程中生物材料诱导的微环境及免疫调控。
本书适合材料学、生物工程、医学等多领域的读者阅读，可供相关领域的研究生和教师选作教学参考，亦可供科研人员选作专业读物。
![作者简介]()
戴尅戎，中国工程院院士，法国国家医学科学院外籍通信院士。先后担任上海第二医学院（现上海交通大学医学院）附属第九人民医院终身教授、骨科主任、院长，上海市创伤骨科与骨关节疾病临床医学中心首席科学家、数字医学临床转化教育部工程研究中心主任、上海交大医学3D打印创新研究中心主任、上海交通大学转化医学研究院干细胞与再生医学转化基地主任。曾被授予首届上海市发明家、97香港杰出中国访问学人、上海市科技功臣、何梁何利基金科学与技术奖、吴阶平医学奖、法国地中海大学荣誉博士和澳大利亚西澳大学Raine访问教授等荣誉称号与奖项。
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List of Contributors
Preface
1.Material characteristics, surface/interface, and biological effects on the osteogenesis of bioactive materials
1.1 Fabrication methods of bioactive materials for bone regeneration
1.1.1 Material characteristics of bioactive materials for bone regeneration
1.1.2 Design of porous bioactive materials
1.1.3 Main challenges and prospects
References
1.2 Surface micro-/nanostructure regulation of bioactive materials for osteogenesis
1.2.1 Surface morphology of bioactive materials for osteogenesis
1.2.2 Porosity of bioactive porous materials for osteogenesis
1.2.3 Grain size of bioactive materials for osteogenesis
1.2.4 Summary
References
1.3 Protein adsorption on bioactive materials and its effect on osteogenesis
1.3.1 Current methods for studying protein adsorption
1.3.2 Material factors influencing protein adsorption
1.3.3 The effect of protein adsorption on the osteogenesis of bioactive materials
1.3.4 Summary
References
1.4 Osteogenesis induced by bioactive porous materials and the related molecular mechanism
1.4.1 Angiogenesis of bioactive materials and the involved molecular mechanism
1.4.2 Osteogenesis of bioactive materials and material_mediated mesenchymal stem cell function
1.4.3 Role of immunoresponse in the osteogenesis of bioactive materials
1.4.4 Summary
References
2.Biomaterial-induced microenvironment and host reaction in bone regeneration
2.1 Bioactive inorganic ions for the manipulation of osteoimmunomodulation to improve bone regeneration
2.1.1 Introduction
2.1.2 Application of bioactive ions in developing bone biomaterials and their possible application in manipulating
osteoimmunomodulation
2.1.3 Combining bioactive elements to develop novel bone biomaterials with osteoimmunomodulatory properties as well as promote
osteogenesis
2.1.4 Summaries and future prospects
References
2.2 Silicate-based bone cements for hard tissue regeneration
2.2.1 Preparation of silicate-based bone cement
2.2.2 Self-setting properties and drug delivery performance of silicate-based bone cement
2.2.3 In vitro and in vivo bioactivity and osteoinductivity of silicate-based bone cement
References
2.3 Trace element–based biomaterials for osteochondralregeneration
2.3.1 Introduction
2.3.2 Biomaterials for osteochondral regeneration
2.3.3 Trace element–based biomaterials for osteochondral regeneration
2.3.4 Conclusions and perspectives
References
2.4 Bioactive ions for bone tissue engineering design
2.4.1 Introduction
2.4.2 Effects of bioactive ions on cell proliferation and stemness maintenance
2.4.3 Effects of bioactive ions on osteogenesis and osteoclastogenesis
2.4.4 Effects of bioactive ions on angiogenesis
2.4.5 Design of bioactive ion composite biomaterials for bone tissue engineering
2.4.6 Conclusions and perspectives
References
3.A bone regeneration concept based on immune microenvironment regulation
3.1 Characteristics of the immune microenvironment in biomaterial-based regeneration
3.1.1 Immune response after biomaterial implantation
3.1.2 Macrophage in bone-relevant physiological and pathological processes
3.1.3 T cells and B cells in bone-relevant physiological and pathological processes
3.1.4 Dendritic and natural killer cells in bone-relevant physiological and pathological processes
References
3.2 Biomaterials and their degradation products in the immune microenvironment and regeneration
3.2.1 Metallic implants, the immune microenvironment, and regeneration
3.2.2 Inorganic materials implants, immune microenvironment, and regeneration
3.2.3 Organic materials implants, immune microenvironment, and regeneration
References
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