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    • 作者: 李校堃著
    • 出版社: 高等教育出版社
    • 出版时间:2019-10-01 00:00:00
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    商品参数
    • 作者: 李校堃著
    • 出版社:高等教育出版社
    • 出版时间:2019-10-01 00:00:00
    • 版次:2
    • 印次:1
    • 印刷时间:2019-10-01
    • 字数:1900000
    • 页数:1040
    • 开本:16开
    • 装帧:平装
    • ISBN:9787040528695
    • 国别/地区:中国
    • 版权提供:高等教育出版社

    成纤维细胞生长因子

    作  者:李校堃 著
    定  价:420
    出 版 社:高等教育出版社
    出版日期:2019年10月01日
    页  数:1040
    装  帧:精装
    ISBN:9787040528695
    主编推荐

    内容简介

    FGF是多基因家族,各成员之间具有一定的序列同源性和结构相似性。在人体许多组织内,具有广泛的生物学活性,参与一系列重要的生理和病理过程,具有临床治疗的潜在效果。本书共分九章,从FGF总论、FGF与受体及其结构与功能、FGF与疾病和FGF与生物工程等角度,系统整理了国内外有关FGF的近期新研究成果,阐述了FGF基础研究和应用方面的进展和成果。

    作者简介

    精彩内容

    目录
    The FGF Metabolic Axis
    Chapter 1 Growth Factors Reviews
    Fibroblast growth factors,old kids on the new block
    Pharmacological application of growth factors: basic and clinical
    Cytokines and diabetes research
    Small molecule inhibition of fibroblast growth factor receptors in cancer
    Research advances in tissue engineering materials for sustained release of growth factors
    Minireview: roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases
    Physiological and pharmacological roles of FGF21 in cardiovascular diseases
    Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
    Delivery of growth factor-based therapeutics in vascular diseases: challenges and strategies
    Fibroblast growth factor 10 in pancreas development and pancreatic cancer
    Chapter 2 Injury Repair and Regeneration
    TAT-mediated acidic fibroblast growth factor delivery to the dermis improves wound healing of deep skin tissue in rat
    Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protectzion in a
    rat model of spinal cord injury
    The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo
    Exogenous basic fibroblast growth factor inhibits ER Stress-induced apoptosis and improves recovery from spinal cord injury
    FGF10 protects against renalischemia/reperfusion injury by regulating autophagy and infiammatory signaling
    Reduction of cellular stress is essential for Fibroblast growth factor 1 treatment for diabetic nephropathy
    Chapter 3 Endocrinology and Metabolism
    Fibroblast growth factor 21 (FGF21) therapy attenuates left ventricular dysfunction and metabolic disturbance by improving
    FGF21 sensitivity,cardiac mitochondrial redox homoeostasis and structural changes in pre-diabeticrats
    NMR-based metabolomics reveal a recovery from metabolic changes in the striatum of 6-OHDA-induced rats treated with basic
    fibroblast growth factor
    FGF21 mediates alcohol-induced adipose tissuelipolysis by activation of systemic release of catecholamine inmice
    Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
    Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
    FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
    Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and
    induction of adiponectininmice
    Attenuation of hyperlipidemia and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration
    offibroblast growth factor-21 is associated with suppression of renal infiammation
    The prevention of diabetic cardiomyopathy by non-mitogenic acidic fibroblast growth factor is probably mediated by the
    suppression of oxidative stress and damage
    Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a
    PI3K/Akt signaling-dependent manner
    ……
    Chapter 4 Structure and Modification
    Chapter 5 Signaling Pathway and Pharmacology
    Chapter 6 Pharmaceutics and New Material
    Chapter 7 Bioreactor and Engineering
    Chapter 8 FGFR and Inhibitors
    Chapter 9 Others

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